SMBM aims to bring together researchers from text and data mining in biomedicine, medical, bio- and chemoinformatics, and researchers from biomedical ontology design and engineering. SMBM 2016 is the follow-up event to SMBM 2014 (University of Aveiro, Portugal), SMBM 2012 (University of Zürich, Switzerland), SMBM 2010 (EBI, U.K.), SMBM 2008 (University of Turku, Finland), SMBM 2006 (University of Jena, Germany), and SMBM 2005 (EBI, U.K.).