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Interaction of Cep135 with a p50 dynactin subunit in mammalian centrosomes. Kuriyama R , Matuliene J , Terada Y , Uetake Y Cell Motil Cytoskeleton. 2004 May; 58(1): 53-66 Pmid : 14983524
| ... Exogenous p50 lacking the Cep 135-binding domain failed to locate at the centrosome, suggesting that Cep1 ... failed to locate at the centrosome, suggesting that Cep135 is required for initial targeting of the centrosome ... | |
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Characterization of Cep135, a novel coiled-coil centrosomal protein involved in microtubule organization in mammalian cells. Essner R , Kuriyama R , Ohta T , Palazzo R , Ryu J , Uetake Y J Cell Biol. 2002 Jan; 156(1): 87-99 Pmid : 11781336
| ... Cep135 resulted in the accumulation of unique whorl-like particles in both the centrosome and the cytoplasm ... Cep135 is located at the centrosome throughout the cell cycle, and localization is independent of the microtubule ... | |
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A novel function of CEP135 as a platform protein of C-NAP1 for its centriolar localization. Chang J , Kim K , Lee S , Rhee K Exp Cell Res. 2008 Dec; 314(20): 3692-700 Pmid : 18851962
| ... Most of the core centrosomal proteins contain extensive coiled-coil domains, suggesting that the protein-protein interaction is ... coiled-coil domains, suggesting that the protein-protein interaction is a critical force for the core centrosome configuration ... | |
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Filamentous polymers induced by overexpression of a novel centrosomal protein, Cep135. Essner R , Kuriyama R , Ohta T , Ryu J Microsc Res Tech. 2000 Jun; 49(5): 478-86 Pmid : 10842375
| ... To evaluate how the protein is arranged in the centrosomal structure, we overexpressed Cep135 polypeptides in CHO ... protein is arranged in the centrosomal structure, we overexpressed Cep135 polypeptides in CHO cells by transient transfection ... | |
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Plk4-induced centriole biogenesis in human cells. Habedanck R , Kleylein-Sohn J , Le Clech M , Nigg E , Stierhof Y , Westendorf J Dev Cell. 2007 Aug; 13(2): 190-202 Pmid : 17681131
| ... We show that overexpression of Polo-like kinase 4 (Plk4) in human cells induces centrosome amplification through the ... Plk4) in human cells induces centrosome amplification through the simultaneous generation of multiple procentrioles adjoining each parental centriole ... | |
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Stepwise evolution of the centriole-assembly pathway. Bettencourt-Dias M , Branco P , Carvalho-Santos Z , Machado P , Pereira-Leal J , Rodrigues-Martins A , Tavares-Cadete F J Cell Sci. 2010 May; 123(Pt): 1414-26 Pmid : 20392737
| ... in the evolution of CBB components and show that, in the case of BLD10/CEP135, this is ... Given the diversity of cellular contexts encountered in eukaryotes, but the remarkable conservation of CBB morphology, we asked ... | |
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Drosophila bld10 is a centriolar protein that regulates centriole, basal body, and motile cilium assembly. Megraw T , Mottier-Pavie V Mol Biol Cell. 2009 May; 20(10): 2605-14 Pmid : 19321663
| ... Chlamydomonas reinhardtii Bld10p and human Cep135, is a ubiquitous centriolar protein that also localizes to the spermatid ... Bld10p and human Cep135, is a ubiquitous centriolar protein that also localizes to the spermatid basal body ... | |
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A proximal centriole-like structure is present in Drosophila spermatids and can serve as a model to study centriole duplication. Avidor-Reiss T , Blachon S , Cai X , Church A , Polyanovsky A , Roberts K , Yang K Genetics. 2009 May; 182(1): 133-44 Pmid : 19293139
| ... a mutation in the gene encoding the conserved centriolar protein POC1, which is part of the daughter centriole ... during the evolution of insects, the proximal centriole was simplified by eliminating the later steps in centriole assembly ... | |
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Centrosome amplification in CHO and DT40 cells by inactivation of cyclin-dependent kinases. Beishir S , Breslin L , Hochegger H , Kuriyama R , Morrison C , Smith E , Steere N , Wagner M Cytoskeleton (Hoboken). 2011 Aug; 68(8): 446-58 Pmid : 21766470
| ... Thus centrosome amplification results from the discoordination of the centrosome cycle from the progression of other cell cycle ... the arrest, allowing rapid centrosome multiplication upon recovery from the cell cycle arrest or expression of exogenous Plk4 ... | |
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Gamma-tubulin-containing abnormal centrioles are induced by insufficient Plk4 in human HCT116 colorectal cancer cells. Arnold M , Bettencourt-Dias M , Hoffmann I , Kuriyama R , Sandvig L J Cell Sci. 2009 Jun; 122(Pt): 2014-23 Pmid : 19454482
| ... The amount of Plk4 at each centrosome was less in cells with abnormal centrosomes than cells without gamma ... Although gamma-tubulin seems to exist as a ring complex, the abnormal structures do not support microtubule nucleation ... | |
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Dynamic organization of microtubules and microtubule-organizing centers during the sexual phase of a parasitic protozoan, Lecudina tuzetae (Gregarine, Apicomplexa). Besse C , Gèze M , Kuriyama R , Omoto C , Schrével J Cell Motil Cytoskeleton. 2005 Dec; 62(4): 195-209 Pmid : 16240430
| ... microscopy, we have characterized the dynamic changes in microtubule organization during the sexual phase of the life cycle ... microtubules and microtubule bundles originating from the protruding apical end corresponding to the dehiscence pole of the sporocyst ... | |
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Binding of the V proteins to the nucleocapsid proteins of human parainfluenza type 2 virus. Ito M , Ito Y , Kawano M , Komada H , Nishio M , Ohgimoto S , Suga S , Tsurudome M , Watanabe N Med Microbiol Immunol. 1996 Sep; 185(2): 89-94 Pmid : 8884740
| ... the NP proteins and that the N-terminal domain of V protein interacts directly with the NP proteins ... We examined the interaction of the NP proteins and the P, V proteins or deletion mutants of V ... | |
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How do proteins find mitochondria? Kolata G Science. 1985 Jun; 228(4707): 1517-8 Pmid : 4012306
| ... How do proteins find mitochondria ... | |
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Does the HIV Nef protein mimic the MHC? Hobohm U , Sander C FEBS Lett. 1993 Nov; 333(3): 211-3 Pmid : 8224180
| ... The sequence of the HIV Nef protein has no significant homology to other proteins in the SwissProt database ... Using a novel protein sequence comparison method, we find similarities between different Nef sequences and the alpha chain ... | |
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Recruitment of proteins to modulate protein-protein interactions. Liu J Chem Biol. 1999 Aug; 6(8): R213-5 Pmid : 10421765
| ... The use of a 'borrowed' protein surface to either enhance or inhibit the interaction of a small ligand ... This approach represents a general method for modulating protein-protein interactions and may find many applications in both ... | |
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Prevalence of M-proteins in serum of hospitalized patients. Physicians' response to finding M-proteins in serum protein electrophoresis. Vladutiu A Ann Clin Lab Sci. 1987 May; 17(3): 157-61 Pmid : 3606022
| ... The frequency of M-proteins (1.1 percent) in the hospitalized patients was higher than that reported for ... M-proteins (tall, narrow spikes) are the major finding in serum protein electrophoresis (SPE), and their presence could ... | |
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In vitro carboxymethylation of myelin basic protein. Innami T , Kakimoto Y , Miyake M Neurosci Res. 1986 Dec; 4(2): 143-51 Pmid : 2433649
| ... The activities of the two carboxymethylases were high in the rat brain in comparison to the other rat ... activities of the two carboxymethylases were high in the rat brain in comparison to the other rat organs ... | |
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Finding intermediates in protein folding. Baldwin R Bioessays. 1994 Mar; 16(3): 207-10 Pmid : 8166675
| ... Finding intermediates in protein folding ... | |
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Finding and filling protein cavities using cellular logic operations. Delaney J J Mol Graph. 1992 Sep; 10(3): 174-7 Pmid : 1467333
| ... So far the main use of the method has been in visualizing protein active sites for docking ... The operations used to fill the cavities also can be used to process the filler to filter out ... | |
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Dural sinus thrombosis associated with activated protein C resistance: MR imaging findings and proband identification. Barboriak D , Ortel T , Provenzale J AJR Am J Roentgenol. 1998 Feb; 170(2): 499-502 Pmid : 9456973
| ... be important not only in helping to explain the cause of thrombosis in affected individuals but also in ... A positive finding for activated protein C resistance can be important not only in helping to explain the ... | |
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Defective protein C in uraemia. Dyerberg J , Knudsen F , Nielsen A , Sørensen P Blood Purif. 1987 1987 ; 5(1): 29-32 Pmid : 3790269
| ... us to suggest the presence of one or more inhibitors of protein C activity in plasma from patients ... suggest the presence of one or more inhibitors of protein C activity in plasma from patients with uraemia ... | |
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Factitious proteinuria: diagnosis and protein identification by use of isoelectric focusing. Mallick N , Neary R , Rawlinson P , Sutcliffe H , Thakker B Clin Chem. 1988 Aug; 34(8): 1653-5 Pmid : 3402073
| ... by the disparity between the clinical history and findings and the 24-h excretion of protein in urine ... aroused by the disparity between the clinical history and findings and the 24-h excretion of protein in ... | |
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hnRNP proteins: localization and transport between the nucleus and the cytoplasm. Dreyfuss G , Piñol-Roma S Trends Cell Biol. 1993 May; 3(5): 151-5 Pmid : 14731609
| ... Several of the hnRNP proteins shuttle continuously between the nucleus and the cytoplasm, and the reaccumulation of the ... nucleus and the cytoplasm, and the reaccumulation of the exported hnRNP proteins in the nucleus occurs by a ... | |
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Finding Cinderella's slipper--proteins that fit. Benkovic S , Ostermeier M Nat Biotechnol. 1999 Jul; 17(7): 639-40 Pmid : 10409352
| ... Finding Cinderella's slipper--proteins that fit ... | |
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Researchers find new role for cell cycle proteins. Marx J Science. 1994 Feb; 263(5150): 1093-1093 Pmid : 8108726
| ... Researchers find new role for cell cycle proteins ... | |
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[Current findings on Ca2+ channel proteins]. Krizanová O Cesk Fysiol. 1988 1988 ; 37(4): 319-29 Pmid : 2846188
| ... Current findings on Ca2+ channel proteins ... | |
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Can researchers find recipe for proteins and chips? Abbott A , Dalton R Nature. 1999 Dec; 402(6763): 718-9 Pmid : 10617186
| ... Can researchers find recipe for proteins and chips ... | |
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An EXCEL-based method to search for potential Ser/Thr-phosphorylation sites in proteins. Wera S Comput Methods Programs Biomed. 1999 Jan; 58(1): 65-8 Pmid : 10195647
| ... The input of the program is a protein sequence in single letter code ... The output is a list of these sites and their position in the sequence ... | |
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Structural classification of proteins: new superfamilies. Murzin A Curr Opin Struct Biol. 1996 Jun; 6(3): 386-94 Pmid : 8804825
| ... The structural classification of proteins reveals that it is already more likely to find that a new protein ... already more likely to find that a new protein structure has similarity to another structure than to find ... | |
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Effects of tetracyclines on the production of extracellular proteins by members of the propionibacteriaceae. Chopra I , Hacker K FEMS Microbiol Lett. 1989 Jul; 51(1): 21-4 Pmid : 2792736
| ... The effect of tetracyclines on the synthesis of proteins in Propionibacterium avidum and P ... The effect of tetracycline and other analogues on the synthesis of secreted proteins was also examined in P ... | |
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Factitious proteinuria in a young girl. Hirata Y , Kimura K , Matsuoka H , Nanba S , Ohkubo A , Sugimoto T , Tojo A , Watanabe N Clin Nephrol. 1990 Jun; 33(6): 299-302 Pmid : 2376092
| ... and that egg proteins were injected into the bladder, as they were also present in the bladder urine ... Electrophoresis of the urinary protein showed two abnormal fractions at the alpha and beta globulins ... | |
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Amino acid sequence homology between rat prostatic steroid binding protein and rabbit uteroglobin. Baker M Biochem Biophys Res Commun. 1983 Jul; 114(1): 325-30 Pmid : 6683965
| ... between proteins, I find that the polypeptide chain of rabbit uteroglobin has amino acid sequence homology with the ... Using a computer program designed to detect evolutionary relationships between proteins, I find that the polypeptide chain of ... | |
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Cow's milk protein/soy protein allergy: gastrointestinal imaging. Issenman R , Richards D , Somers S , Stevenson G Radiology. 1988 Jun; 167(3): 721-3 Pmid : 3363128
| ... s milk protein/soy protein allergy, which was diagnosed on the basis of clinical features and histologic findings ... of cow's milk protein/soy protein allergy, which was diagnosed on the basis of clinical features and ... | |
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[Acute phase proteins (C-reactive protein, orosomucoid, haptoglobin)--specific markers in the diagnosis of inflammatory adnexal diseases]. Krämer M , Künzig H , Prinz H , Schmidt-Rohde P Geburtshilfe Frauenheilkd. 1985 Dec; 45(12): 881-6 Pmid : 4085763
| ... to the present in normal clinical routine, were only partially useful in the diagnosis of an inflammatory adnexal ... the present in normal clinical routine, were only partially useful in the diagnosis of an inflammatory adnexal lesion ... | |
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Nucleotide composition of genes and hydrophobicity of the encoded proteins. Kypr J , Mázek J FEBS Lett. 1992 Jun; 305(2): 163-5 Pmid : 1618344
| ... usage in genes shows that the drift mainly increases the content of adenine at the expense of thymine ... We find that true proteins are generally more hydrophobic than the corresponding hypothetical proteins encoded by the randomized ... | |
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Finding protein coding regions in genomic sequences. Staden R Methods Enzymol. 1990 1990 ; 183: 163-80 Pmid : 2314274
| ... Finding protein coding regions in genomic sequences ... | |
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The polyribosomal mRNA--protein complex is a dynamic structure. Greenberg J Proc Natl Acad Sci U S A. 1981 May; 78(5): 2923-6 Pmid : 6942411
| ... The metabolism of mRNA--protein complexes present in polyribosomes of mouse L cells was investigated with the aid ... These findings imply that mRNA-associated proteins exchange in the cytoplasm with a pool of free proteins ... | |
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Calmodulin-dependent protein kinase II. Fujisawa H Bioessays. 1990 Jan; 12(1): 27-9 Pmid : 2157401
| ... Three multifunctional protein kinases, cyclic AMP-dependent protein kinase, protein kinase C, and calmodulin-dependent protein kinase II ... protein kinase C, and calmodulin-dependent protein kinase II, are involved in signal transduction in response to their ... | |
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Nonhistone protein with high affinity for histone H1 and HMG 14 protein. Karavanov A Experientia. 1983 Sep; 39(9): 1015-6 Pmid : 6224701
| ... of a nonhistone protein from mouse spleen chromatin with histones HI, H2A and HMG 14 protein is shown ... Nonhistone protein with high affinity for histone H1 and HMG 14 protein ... | |
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The effect of chlorambucil on the biosynthesis of the HMG and histone H1 chromosomal proteins of HEp-2 cells. Aleporou-Marinou V , Ostvold A , Pataryas T , Photopoulou A , Sekeri-Pataryas K , Sourlingas T Biochem Mol Biol Int. 1995 Jun; 36(2): 439-49 Pmid : 7663448
| ... The effect of chlorambucil, a bisalkylating agent, on the biosynthesis of the 5% PCA extractable protein fraction of ... to the same extent as that reported for the core histones of the same cell line [7], while ... | |
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Sos1 rapidly associates with Grb2 and is hypophosphorylated when complexed with the EGF receptor after EGF stimulation. Bowtell D , Hu Y Oncogene. 1996 May; 12(9): 1865-72 Pmid : 8649846
| ... associated with the EGFR is markedly less phosphorylated than the majority of the Sos1 within the cell and ... We find that following EGF stimulation, the Sos1 protein associated with the EGFR is markedly less phosphorylated than ... | |
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Inhibition of cofactor activity of protein S by a complex of protein S and C4b-binding protein. Evidence for inactive ternary complex formation between protein S, C4b-binding protein, and activated protein C. Nishioka J , Suzuki K J Biol Chem. 1990 Jun; 265(16): 9072-6 Pmid : 2140568
| ... These findings suggest that the protein S-C4b-binding protein complex inhibits the cofactor activity of free protein ... inhibits the cofactor activity of protein S for anticoagulant-activated protein C, the interactions between protein S, activated ... | |
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Diminished susceptibility to proteolysis after protein modification by the lipid peroxidation product malondialdehyde: inhibitory role for crosslinked and noncrosslinked adducted proteins. Burcham P , Kuhan Y Arch Biochem Biophys. 1997 Apr; 340(2): 331-7 Pmid : 9143338
| ... In keeping with findings concerning the consequences of protein damage by other carbonyl products of lipid peroxidation, we ... Since significant protein crosslinking occurred during modification with malondialdehyde, we investigated the possibility that crosslinked proteins were acting ... | |
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Nutritional assessment of orthopedic patients. Anderson C , Dreblow D , Moxness K Mayo Clin Proc. 1981 Jan; 56(1): 51-4 Pmid : 6779060
| ... Forty-eight percent of the patients had one or more abnormal findings suggestive of protein-calorie malnutrition ... patients, whereas one or more abnormal nutrition-related findings improved to reach the normal range in six patients ... | |
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Amino acid sequence homology between the C3 chain of rat prostatic steroid binding protein and human alpha 2-macroglobulin. Baker M Biochem Biophys Res Commun. 1984 Jul; 122(2): 662-7 Pmid : 6205654
| ... between proteins, I find that exon 2 of the C3 chain of rat prostatic steroid binding protein has ... Amino acid sequence homology between the C3 chain of rat prostatic steroid binding protein and human alpha 2 ... | |
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Finding prospective partners in the library: the two-hybrid system and phage display find a match. Allen J , Edwards M , Elledge S , Walberg M Trends Biochem Sci. 1995 Dec; 20(12): 511-6 Pmid : 8571453
| ... The two-hybrid system uses the efficacy of yeast genetic assays to identify protein-protein interactions ... Finding prospective partners in the library: the two-hybrid system and phage display find a match ... | |
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Pieces of the true grail: a G protein finds its target. Bourne H Science. 1997 Dec; 278(5345): 1898-9 Pmid : 9417637
| ... Pieces of the true grail: a G protein finds its target ... | |
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Recent findings on the mechanism of glutamine stimulation of protein and carbohydrate anabolism. Rennie M Clin Nutr. 1990 Feb; 9(1): 33-4 Pmid : 16837318
| ... Recent findings on the mechanism of glutamine stimulation of protein and carbohydrate anabolism ... | |
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Spore coat protein of Bacillus subtilis--a summary of recent findings. Pandey N Int J Biochem. 1980 1980 ; 12(4): 553-8 Pmid : 6775989
| ... Spore coat protein of Bacillus subtilis--a summary of recent findings ... | |
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Finding protein-binding sites in DNA sequences: the next generation. Frech K , Quandt K , Werner T Trends Biochem Sci. 1997 Mar; 22(3): 103-4 Pmid : 9066261
| ... Finding protein-binding sites in DNA sequences: the next generation ... | |
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