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Molecular phylogenetics of Diseae (Orchidaceae): a contribution from nuclear ribosomal ITS sequences. Chase M , Douzery E , Kores P , Kurzweil H , Linder H , Pridgeon A Am J Bot. 1999 Jun; 86(6): 887-99 Pmid : 10371730
| ... Nuclear ribosomal ITS1, 5.8S rDNA, and ITS2 sequences were compared for 30 Diseae, 20 Orchideae, and four ... 8S rDNA, and ITS2 sequences were compared for 30 Diseae, 20 Orchideae, and four Cranichideae and Diurideae outgroups ... | |
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Nervous system diseaes involving gap junctions. Campos de Carvalho A , Rozental R , Spray D Brain Res Brain Res Rev. 2000 Apr; 32(1): 189-91 Pmid : 10970142
| ... Nervous system diseaes involving gap junctions ... | |
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Mirtazapine: a review of its use in major depression. Holm K , Markham A Drugs. 1999 Apr; 57(4): 607-31 Pmid : 10235695
| ... Mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA) which has predominantly been evaluated in the treatment of ... There was a greater tendency for SSRI-related adverse events with fluoxetine than with mirtazapine, but, overall, mirtazapine ... | |
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Review of the results from clinical studies on the efficacy, safety and tolerability of mirtazapine for the treatment of patients with major depression. Barkin R , Fawcett J J Affect Disord. 1998 Dec; 51(3): 267-85 Pmid : 10333982
| ... The enhancement of serotonergic neurotransmission is specifically mediated via 5-HT1 receptors because mirtazapine is a postsynaptic serotonergic ... Mirtazapine is well absorbed from the gastrointestinal tract following oral administration, and it is extensively metabolized in the ... | |
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Did Lady Macbeth have a mind diseas'd'? ( a medico-legal enigma). Prins H Med Sci Law. 2001 Apr; 41(2): 129-34 Pmid : 11368393
| ... In this contribution, an attempt is made to show her in a somewhat different light ... in doing so, some implications for forensic-psychiatric practice are suggested ... | |
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'Canst thou not minister to a mind diseas'd?: Shakespeare, the theatre and the Elizabethan psyche. Bristow C J R Soc Med. 1988 Apr; 81(4): 193-5 Pmid : 3286864
| ... Canst thou not minister to a mind diseas'd ... | |
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Neurochemical effects of the enantiomers of mirtazapine in normal rats. Burrows G , McGrath C , Norman T Eur J Pharmacol. 1998 Sep; 356(2-3): 121-6 Pmid : 9774241
| ... Male Sprague-Dawley rats received either (+)-mirtazapine, (-)-mirtazapine, (+/-)-mirtazapine or vehicle, by intraperitoneal injection for two weeks ... Chronic drug treatment potentiated this response, with (+/-)-mirtazapine > (-)-mirtazapine > (+)-mirtazapine ... | |
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Phylogenetic relationships in Disa based on non-coding trnL-trnF chloroplast sequences: evidence of numerous repeat regions. Bellstedt D , Harley E , Linder H Am J Bot. 2001 Nov; 88(11): 2088-100 Pmid : 21669640
| ... Within Diseae, 41 species of Disa, two of Brownleea, three of Satyrium, and two of Corycium were included ... five weakly supported the paraphyly of Diseae, with the successive divergence of Brownleea, Corycium, Habenaria, Satyrium, and Disa ... | |
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A comparison of the physicochemical and biological properties of mirtazapine and mianserin. De Boer T , Delbressine L , Funke C , Kelder J , Leysen D , Nickolson V J Pharm Pharmacol. 1997 Apr; 49(4): 403-11 Pmid : 9232538
| ... particular, which is conjugated to the changed aromatic ring, is less negatively charged in mirtazapine than in mianserin ... mirtazapine is, therefore, more polar than mianserin and this is reflected in a lower retention index ... | |
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Mirtazapine, an antidepressant. Puzantian T Am J Health Syst Pharm. 1998 Jan; 55(1): 44-9 Pmid : 9437474
| ... It is biotransformed by hepatic demethylation and is suitable for once-daily doses ... Mirtazapine is a new anti-depressant that blocks presynaptic alpha 2-adrenergic receptors and postsynaptic serotonin type 2 ... | |
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Mirtazapine: a newer antidepressant. Hartmann P Am Fam Physician. 1999 Jan; 59(1): 159-61 Pmid : 9917581
| ... Although mirtazapine has been used successfully in Europe for a number of years, its place in the care ... Many clinicians consider mirtazapine a second-line or even third-line antidepressant to be used when older antidepressants ... | |
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Mirtazapine versus amitriptyline in the long-term treatment of depression: a double-blind placebo-controlled study. Montgomery S , Reimitz P , Zivkov M Int Clin Psychopharmacol. 1998 Mar; 13(2): 63-73 Pmid : 9669186
| ... The significant advantage for mirtazapine compared with placebo was also seen in the prophylactic phase of treatment after ... advantage for mirtazapine compared with placebo was also seen in the prophylactic phase of treatment after 20 weeks ... | |
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Tissue distribution of mirtazapine (Remeron) in postmortem cases. Levine B , Moore K , Saki S , Schames J , Smialek J , Smith M J Anal Toxicol. 1999 Oct; 23(6): 541-3 Pmid : 10517564
| ... the parent compound were consistently greater than the blood concentrations, urine is an adequate screening specimen for mirtazapine ... However, because the liver mirtazapine concentrations were 5-30 times the blood concentrations, the potential for postmortem redistribution ... | |
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Clinical efficacy of mirtazapine: a review of meta-analyses of pooled data. Kasper S Int Clin Psychopharmacol. 1995 Dec; 10: 25-35 Pmid : 8930007
| ... from the moderately or severely depressed patients in the comparative studies of mirtazapine and placebo or mirtazapine and ... the moderately or severely depressed patients in the comparative studies of mirtazapine and placebo or mirtazapine and amitriptyline ... | |
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Mirtazapine--another new class of antidepressant. no authors listed Drug Ther Bull. 1999 Jan; 37(1): 1-3 Pmid : 10562767
| ... The manufacturer claims that mirtazapine is "effective in all types of depression", with "minimal serotonergic, anticholinergic and antiadrenergic ... Is mirtazapine an advance on existing drugs ... | |
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Mirtazapine: clinical advantages in the treatment of depression. Burrows G , Kremer C J Clin Psychopharmacol. 1997 Apr; 17: 34S-39S Pmid : 9090576
| ... The overall improvement with mirtazapine is seen after 1 week of treatment and is sustained throughout the treatment ... overall improvement with mirtazapine is seen after 1 week of treatment and is sustained throughout the treatment period ... | |
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First report of mirtazapine overdose. Hoes M , Zeijpveld J Int Clin Psychopharmacol. 1996 Jun; 11(2): 147-147 Pmid : 8803652
| ... This report describes what is thought to be the first case of mirtazapine overdose occurring since the introduction ... It is suggested that mirtazapine has a benign side effect profile when taken in overdose ... | |
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The pharmacologic profile of mirtazapine. de Boer T J Clin Psychiatry. 1996 1996 ; 57: 19-25 Pmid : 8636062
| ... Mirtazapine (Org 3770) is a new antidepressant with prominent alpha 2-adrenergic auto- and heteroreceptor antagonistic properties ... Mirtazapine has a low affinity for 5-HT1A receptors but shows 5-HT1A-agonistic-like effects in a ... | |
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Mirtazapine-induced hepatotoxicity. Hui C , Lai C , Lam S , Wong W , Yuen M J Clin Gastroenterol. 2002 Sep; 35(3): 270-1 Pmid : 12192206
| ... In the first case, mirtazapine was prescribed for 3 years and the patient developed derangement in liver function ... Two women treated for depression with mirtazapine developed severe hepatotoxicity because of the drug ... | |
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Pharmacokinetics and biotransformation of mirtazapine in human volunteers. Delbressine L , Jacobs P , Kaspersen F , Moonen M , Paanakker J , Timmer C , van Hal H , Voortman G , Wagenaars G Clin Drug Investig. 1998 1998 ; 15(1): 45-55 Pmid : 18370465
| ... As mirtazapine is marketed as a racemic mixture and both enantiomers possess pharmacological properties essential for the overall ... both enantiomers possess pharmacological properties essential for the overall activity of the racemate, the pharmacokinetics of mirtazapine were ... | |
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Mirtazapine : A Review of its Pharmacology and Therapeutic Potential in the Management of Major Depression. Davis R , Wilde M CNS Drugs. 1996 May; 5(5): 389-402 Pmid : 26071050
| ... The recommended starting dosage of mirtazapine is 15 mg/day for 4 days, then 30 mg/day for ... starting dosage of mirtazapine is 15 mg/day for 4 days, then 30 mg/day for 10 days ... | |
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Pharmacokinetics of mirtazapine from orally administered tablets: influence of a high-fat meal. Cohen M , Huisman J , Panagides J , Timmer C Eur J Drug Metab Pharmacokinet. 1997 Apr; 22(2): 103-10 Pmid : 9248777
| ... Serial blood samples were taken and pharmacokinetic parameters calculated and statistically analyzed from mirtazapine plasma levels ... Food intake was shown to have no influence on the elimination of mirtazapine, as measured by its elimination ... | |
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Mirtazapine revisited. Rosenbaum J Am Fam Physician. 1997 Dec; 56(9): 2190-2 Pmid : 9402808
| ... Mirtazapine revisited ... | |
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Mirtazapine--a new antidepressant. no authors listed Med Lett Drugs Ther. 1996 Dec; 38(990): 113-4 Pmid : 8988154
| ... Mirtazapine--a new antidepressant ... | |
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[Mirtazapine--the new standard]. no authors listed Fortschr Neurol Psychiatr. 1999 Aug; 67(8): 1-4 Pmid : 10511867
| ... Mirtazapine--the new standard ... | |
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Safety of mirtazapine in overdose. Bremner J , Walshe T , Wingard P J Clin Psychiatry. 1998 May; 59(5): 233-5 Pmid : 9632033
| ... We report 6 confirmed cases of substantial overdose with mirtazapine, a new antidepressant compound, that occurred up to ... In 6 patients, the mirtazapine doses ranged from 10 to 30 times the maximum recommended dose, and there ... | |
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A multicentre, double-blind, amitriptyline-controlled study of mirtazapine in patients with major depression. Bennie E , Bhatt G , Fenton G , Lodge A , McCreadie R , Mullin J J Psychopharmacol. 1996 Jan; 10(3): 235-40 Pmid : 22302951
| ... this study shows that mirtazapine is as effective as amitriptyline in treating major depression, while at the same ... that mirtazapine is as effective as amitriptyline in treating major depression, while at the same time better tolerated ... | |
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Indirect in vivo 5-HT1A-agonistic effects of the new antidepressant mirtazapine. Berendsen H , Broekkamp C Psychopharmacology (Berl). 1997 Oct; 133(3): 275-82 Pmid : 9361334
| ... mirtazapine (0.32 mg/kg) could be prevented if the mice were pre-exposed to injections with mirtazapine ... No familiarization for the mirtazapine stimulus was obtained by pre-exposure to (+/-)-1-(2,5-dimethoxy-4-iodophenyl ... | |
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Dysthymic disorder: treatment with mirtazapine. Bea C , Budech C , Dunner D , Hendrickson H , O'Connor E Depress Anxiety. 1999 1999 ; 10(2): 68-72 Pmid : 10569129
| ... Mirtazapine is an antidepressant which has been recently released on the U ... We studied the effects of 15 to 45 mg of mirtazapine in 15 patients with dysthymic disorder on ... | |
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Mirtazapine and its enantiomers differentially modulate acute thermal nociception in rats. Freynhagen R , Lipfert P , Muth-Selbach U , Vogt J Brain Res Bull. 2006 Mar; 69(2): 168-73 Pmid : 16533666
| ... Wistar rats were injected intrathecal with either (+/-)-mirtazapine, R(-)-mirtazapine, S(+)-mirtazapine from 1 to 0.001 mg ... mirtazapine, R(-)-mirtazapine, S(+)-mirtazapine from 1 to 0.001 mg/kg and vehicle (0.9% NaCl), respectively ... | |
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Mirtazapine in recurrent brief depression. Aschauer H , de Zwaan M , Kasper S , Pezawas L , Stamenkovic M Int Clin Psychopharmacol. 1998 Jan; 13(1): 39-40 Pmid : 9988366
| ... Consequently, mirtazapine might be a treatment option for patients with RBD ... Mirtazapine is a noradrenergic with specific selective serotoninergic antidepressant ... | |
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Mirtazapine: efficacy and tolerability in comparison with fluoxetine in patients with moderate to severe major depressive disorder. Mirtazapine-Fluoxetine Study Group. Kremer C , Timmerman L , van Moffaert M , Wheatley D J Clin Psychiatry. 1998 Jun; 59(6): 306-12 Pmid : 9671343
| ... D scores at baseline were 26.0 for the mirtazapine- and 26.1 for the fluoxetine-treated group ... at weeks 1-4 were 36.5 mg/day for mirtazapine and 19.6 mg/day for fluoxetine ... | |
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The use of mirtazapine in a patient with chronic pain. Brannon G , Stone K J Pain Symptom Manage. 1999 Nov; 18(5): 382-5 Pmid : 10584463
| ... The newer antidepressant mirtazapine (Remeron) has activity on noradrenergic and serotonergic transmission and is approved for the treatment ... has activity on noradrenergic and serotonergic transmission and is approved for the treatment of a Major Depressive Disorder ... | |
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Suppressive effect of mirtazapine on the HPA system in acutely depressed women seems to be transient and not related to antidepressant action. Dose T , Hennings J , Holsboer F , Horstmann S , Ising M , Kloiber S , Lucae S , Menke A , Spieler D , Uhr M Psychoneuroendocrinology. 2009 Feb; 34(2): 238-48 Pmid : 18926641
| ... term administration of mirtazapine has immediate but only transient suppressive effects on the HPA system predominantly in women ... results confirm that dex/CRH tests can be used as predictors of clinical course also under mirtazapine treatment ... | |
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Mirtazapine, a mixed-profile serotonin agonist/antagonist, suppresses sleep apnea in the rat. Carley D , Radulovacki M Am J Respir Crit Care Med. 1999 Dec; 160(6): 1824-9 Pmid : 10588592
| ... 1 mg/kg +/- mirtazapine (labeled as Remeron), (3) 1 mg/kg mirtazapine, or (4) 5 mg/ kg mirtazapine ... We conclude that mirtazapine, over a 50-fold dose range, significantly reduces central apnea expression during NREM and ... | |
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Fluvoxamine augmentation increases serum mirtazapine concentrations three- to fourfold. Anttila A , Leinonen E , Rasanen L Ann Pharmacother. 2001 Oct; 35(10): 1221-3 Pmid : 11675851
| ... Adding fluvoxamine to treatment with mirtazapine may cause a significant increase in mirtazapine concentration ... Mirtazapine is mainly metabolized by cytochrome P450 isoenzymes CYP1A2, CYP2D6, and CYP3A4 ... | |
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Efficacy of mirtazapine in clinically relevant subgroups of depressed patients. Nutt D Depress Anxiety. 1998 1998 ; 7: 7-10 Pmid : 9597345
| ... Mirtazapine is a noradrenergic and specific serotonergic antidepressant (NaSSA) with a novel mode of action that differs from ... moderately or severely depressed patients have shown mirtazapine to be effective in clinically important subgroups of depressed patients ... | |
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Safety of mirtazapine: a review. Montgomery S Int Clin Psychopharmacol. 1995 Dec; 10: 37-45 Pmid : 8930008
| ... A general indication of mirtazapine's safety is the significantly lower percentage of patients (65%) who complained of ... These complaints were typically mild and transient in nature, and decreased over time despite increased doses of mirtazapine ... | |
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[Two new antidepressants: mirtazapine and venlafaxine]. Birkenhäger T , Moleman P Ned Tijdschr Geneeskd. 1999 May; 143(18): 934-7 Pmid : 10368708
| ... In depressed inpatients with psychotic features, suicidality or a longlasting episode mirtazapine is not effective and in such ... features, suicidality or a longlasting episode mirtazapine is not effective and in such patients venlafaxine was not studied ... | |
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Drug-drug interaction studies with mirtazapine and carbamazepine in healthy male subjects. Maris F , Sitsen J , Timmer C Eur J Drug Metab Pharmacokinet. 2001 Jan; 26(1-2): 109-21 Pmid : 11554425
| ... indicate that carbamazepine decreased significantly AUC and Cmax values for mirtazapine and increased values for demethyl-mirtazapine Cmax ... for another 7 days (Study A) or with mirtazapine combined with placebo for 7 days and subsequently mirtazapine ... | |
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Mirtazapine vs. amitriptyline vs. placebo in the treatment of major depressive disorder. Gilvary E , Glaudin V , Panagides J , Smith W Psychopharmacol Bull. 1990 1990 ; 26(2): 191-6 Pmid : 2236455
| ... Mirtazapine- and amitriptyline-treated patients had statistically significantly greater mean Hamilton Rating Scale for Depression (HAM-D) score ... Results of this study indicate that mirtazapine is more effective than placebo in the treatment of these patients ... | |
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Trait anxiety and the effect of a single high dose of diazepam in unipolar depression. Bruijn J , Moleman P , Mulder P , van den Broek W J Psychiatr Res. 2001 Nov; 35(6): 331-7 Pmid : 11684140
| ... significant differential response to the diazepam test: depressive patients with high trait anxiety showed, predominantly, a disappearance of ... depressive symptoms without sedation and depressive patients with low trait anxiety showed, predominantly, sedation without disappearance of depressive ... | |
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Lack of drug interactions between mirtazapine and risperidone in psychiatric patients: a pilot study. Doorschot C , Loonen A , Oostelbos M , Sitsen J Eur Neuropsychopharmacol. 1999 Dec; 10(1): 51-7 Pmid : 10647097
| ... Results of plasma level measurements are available for six patients and indicate that adding mirtazapine to risperidone does ... antipsychotic (risperidone) and an antidepressant (mirtazapine) with the objective to preliminarily assess a possible pharmacokinetic interaction and the ... | |
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Serotonin transporter polymorphisms and side effects in antidepressant therapy--a pilot study. Heres S , Leucht S , Popp J , Steimer W Pharmacogenomics. 2006 Mar; 7(2): 159-66 Pmid : 16515395
| ... them in combination with other antidepressants), and 44 patients were predominantly treated with antidepressants acting via HTT, such ... were predominantly treated with antidepressants acting via HTT, such as selective serotonin re-uptake inhibitors (SSRIs) and tricyclic ... | |
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Receptor occupancy of mirtazapine determined by PET in healthy volunteers. Audrain H , Bender D , Hansen S , Jakobsen S , Jensen S , Rodell A , Rosenberg R , Smith D , Stork B , Wegener G Psychopharmacology (Berl). 2007 Nov; 195(1): 131-8 Pmid : 17653532
| ... This study determined whether [(11)C]mirtazapine is an appropriate molecular tool for use with PET to estimate ... 11)C]mirtazapine from baseline values, whereas daily intake of mirtazapine markedly decreased the binding potential in cortex ... | |
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Mirtazapine withdrawal symptoms. Benazzi F Can J Psychiatry. 1998 Jun; 43(5): 525-525 Pmid : 9653542
| ... Mirtazapine withdrawal symptoms ... | |
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[Mirtazapin--fast and strong effects]. no authors listed Fortschr Neurol Psychiatr. 1998 Oct; 66(10): 1-4 Pmid : 9830081
| ... Mirtazapin--fast and strong effects ... | |
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A double-blind study comparing the efficacy and tolerability of mirtazapine and doxepin in patients with major depression. Ahlfors U , Jääskeläinen J , Järvi R , Marttila M , Miettinen E , Romanov M , Sorri P , Zivkov M Eur Neuropsychopharmacol. 1995 Dec; 5(4): 441-6 Pmid : 8998395
| ... In conclusion, mirtazapine is an effective treatment for major depression and appears to offer advantages in tolerability over ... conclusion, mirtazapine is an effective treatment for major depression and appears to offer advantages in tolerability over doxepin ... | |
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Pollinators underestimated: a molecular phylogeny reveals widespread floral convergence in oil-secreting orchids (sub-tribe Coryciinae) of the Cape of South Africa. Barraclough T , Pauw A , Savolainen V , Waterman R Mol Phylogenet Evol. 2009 Apr; 51(1): 100-10 Pmid : 18586527
| ... A phylogeny of Diseae is inferred using sequence data from all genera in the tribe, with an emphasis ... Nuclear (ITS) and plastid (trnLF and matK) gene region sequences were analysed for 79 ingroup taxa and three ... | |
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Efficacy and tolerability of mirtazapine versus citalopram: a double-blind, randomized study in patients with major depressive disorder. Nordic Antidepressant Study Group. Agren H , Behnke K , Helsdingen J , Leinonen E , Skarstein J Int Clin Psychopharmacol. 1999 Nov; 14(6): 329-37 Pmid : 10565799
| ... A difference of 2.3 points on MADRS favouring mirtazapine is considered indicative for a clinically relevant superiority ... 3 points on MADRS favouring mirtazapine is considered indicative for a clinically relevant superiority between two proven antidepressants ... | |
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