Personalized Medicine (Sommersemester 2021)

Lecturer: Prof. Dr. Erwin Böttinger (Digital Health - Personalized Medicine)

General Information

• Weekly Hours: 4
• Credits: 6
• Graded: yes
• Enrolment Deadline: 18.03.2021 - 09.04.2021
• Teaching Form: Lecture / Exercise
• Enrolment Type: Compulsory Elective Module
• Course Language: English

Programs, Module Groups & Modules

Description

Lecture starts 04/13/21

Personalized medicine (PM) combines lifestyle, environment, genomic, and biologic information to identify molecular disease mechanisms with the aim of improving prevention, diagnosis and therapy while leading to a more efficient health system. Personalized Medicine is intensely data-driven and leverages health information systems, genomics, data sciences, and digital health methodologies and technologies. Real-world implementations of personalized medicine applications typically integrate digital health technologies and tools.  

This course addresses the specialization areas ‘Digitalization of Clinical and Research Processes (DICR)’, ‘Acquisition, Processing and Analysis of Health Data (APAD)’, and ‘Scalable Computing Algorithms for Digital Health (SCAD)’ of the Digital Health Master program. It is designed to equip students with core knowledge and competencies in data-driven personalized medicine.

The course will deploy a mixed teaching format with lectures, seminars, and case studies with active student participation and a course-spanning in-depth team project.

Students will learn about foundations for Personalized Medicine, including the Human Genome Project and genomic sciences, emerging study designs for personalized health evidence generation, modern real-world biobanking, digital health assistance systems and health risk communication, disruptive health IT platforms and digital health technologies for personalized medicine.

Students will study use cases exemplifying personalized medicine in clinical practice, including pharmacogenomics, precision mental health, clinical genomics, and precision oncology.  

Students will examine in-depth the introductory landmark Topol Report on ‘preparing the personalized, digital future of healthcare’ towards the beginning of the course in May, which will provide a base understanding for several project teams that will conduct an in-depth homework assignment, respectively, for a graded final presentation at the conclusion of the course in July. Lecture/exercise topics throughout the course may enhance the team project experience.  

Learning Objectives:

• Understand and apply the concepts, definitions, approaches and terms in data-driven personalized medicine
• Critically assess impact of challenges and opportunities for personalized medicine
• Learn to make and communicate assessments and decisions on personalized medicine requirements in development and/or implementation of digital health solutions
• Ability to assess scope and sustainable benefits of digital tools, applications, and information in health behavior, prevention and management of disease
• Understand personalized medicine use case examples and how they impact clinical practice
• Apply learnings and work in teams developing a single chosen project throughout the course for an in-depth final presentation

Topics for the lecture

4/13/2021	17:00	18:30	Erwin Böttinger	Introductions and Course Overview
4/15/2021	17:30	19:00	Erwin Böttinger	The Human Genome Project: Scientific Foundations for Personalized Medicine (PM)
4/20/2021	17:00	18:30	Erwin Böttinger	Biobanks - Drivers of Personalized Medicine Discovery and Implementation Research
4/22/2021	15:00	16:30	Erwin Böttinger	How Personalized Medicine and Digitization Transform Healthcare by 2030: Introduction of the 'Topol Report'
4/27/2021	17:00	18:30	Erwin Böttinger	Group Exercise: Topol Report 'Top 10 Digital Healthcare Technologies' and Use Case Scenarios for PerMed
4/29/2021	15:00	16:30	Erwin Böttinger	Continuation of Group Exercise: Topol Report 'Top 10 Digital Healthcare Technologies' and Use Case Scenarios for PM
5/4/2021	17:00	18:30	Erwin Böttinger	Technology Disruptors: Personal Health Platforms U.S.: Apple Health and Google Health
5/6/2021	15:00	16:30	Attila Wohlbrandt	Personal Digital Health Platforms in Europe: Example Smart4Health Platform
5/11/2021	17:00	18:30	Erwin Böttinger	Special Topic Coronavirus Pandemic - Lessons Learned and Open Qestion
5/13/2021				German Holiday
5/18/2021	17:00	18:30	Girish Nadkarni	Best Practices for Implementation of predictive, data-driven models towards personalized medicine
5/20/2021	15:00	16:30	Ben Glicksberg	How digitization of patient data can drive personalized health: use case of machine learning on electrocardiograms
5/25/2021	17:00	18:30	Daniel Lewkowicz	Intelligent Personal Health Assistance
5/27/2021	15:00	16:30	Tamara Slosarek	Personalized Risk Predictionn and Risk Communication
6/1/2021	17:00	18:30	Stefan Konigorski	Emerging ‘N-of-1’ Trial Methodology for Personalized Health - Introduction
6/3/2021	15:00	16:30	Stefan Konigorski	Personalizing Health Behavior with Evidence: Emerging ‘N-of-1’ Trial Methodology
6/8/2021	17:00	18:30	Hanna Drimalla	Precision Mental Health I
6/10/2021	15:00	16:30	Hanna Drimalla	Precision Mental Health II
6/16/2021	15:15	18:30	Noura Abul-Husn	Genomic Medicine
6/22/2021	17:00	18:30	Erwin Böttinger	Precision Oncology
6/24/2021	15:00	16:30	Aniwaa Owusu-Obeng	Principles of Pharmacogenomics
6/29/2021	17:00	18:30	Aniwaa Owusu-Obeng	Principles of Pharmacogenomics II
7/1/2021	15:00	16:30	Böttinger/Stern	Personalized Medicine Agents in Global Health
7/6/2021	17:00	18:30	Erwin Böttinger	Review and discussion of essential course content
7/8/2021	15:00	16:30	Erwin Böttinger	Mock Exam and Exam Preview
7/13/2021	17:00	18:30	Erwin Böttinger	Student Team Assignment Reports
7/15/2021	15:00	16:30	Erwin Böttinger	Student Team Assignment Reports
7/20/2021	17:00	18:30	Erwin Böttinger	Group Exercise: Personalized Medicine Idea Factory
7/22/2021	15:00	16:30	Erwin Böttinger	Final Exam

Literature

• Ashley E. Towards precision medicine: applications of next generation sequencing. Nature Reviews Genetics 17:507-522, 2016
• Pritchard et al. Strategies for integrating personalized medicine in healthcare practice. Personalized Medicine Vol 14(2) Published Online 19 Jan 2017
• Personalized Medicine Coalition. Public perspectives on Personalized Medicine. Survey of U.S. public opinion May 2018
• Personalized Medicine Coalition. The Personalized Medicine Report 2017   
• NHS The Topol Review. Preparing the healthcare workforce to deliver the digital future. An independent report on behalf of the Secretary of State for Health and Social Care, February 2019
• Nikles J, Mitchell G (eds) (2015). The essential guide to N-of-1 trials in health. Dordrecht: Springer.

Learning

Characteristics of Class Meetings/Lectures: Two lectures/seminars/case studies per week

Due to Corona pandemic we will use Zoom Meetings and openHPI course room (link to the course on openHPI will be provided after registration deadline to all registered participants )

Examination

Student presentation: 50% of the final grade.
Written final exam: 50% of the final grade.

Dates

• Tuesday 5pm-6:30pm and Thursday 3pm -4:30pm

&nbs

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