Prof. Dr. Christoph Lippert

Marco Piccininni, PhD

Postdoctoral Researcher

Phone: +49-(0)331 5509-4913

Room: Campus III - Building G2 - G-2.1.34

Email: marco.piccininni(at)hpi.de

Web: ORCID  Google Scholar

Research Interests

Marco Piccininni is a biostatistician with an interest in modern methodological aspects of Health Data Science. In addition to his work on descriptive neuroepidemiology and population-based registries, Marco Piccininni has a particular interest in causal inference and clinical risk prediction, especially exploring the intersections between these traditionally separate domains.

Work Experience

Postdoc,  September 2023  - present
Health Intervention Analytics Lab, Digital Health - Machine Learning Research Group, Hasso Plattner Institute for Digital Engineering, Potsdam, Germany

Research fellow,  March 2021  - August 2023
Neuroepidemiology research group, Center for Stroke Research Berlin, Charité – Universitätsmedizin Berlin, Berlin, Germany

Research fellow,  December 2018  - August 2023
Institute of Public Health, Charité – Universitätsmedizin Berlin, Berlin, Germany

Biostatistician, August 2016  - December 2018
Unit of Neurodegenerative Diseases, Department of Clinical Research in Neurology, University of Bari “Aldo Moro”, at Pia Fondazione Card. G. Panico, Tricase (Lecce), Italy

Biostatistician, April -  August 2018
Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari “Aldo Moro”, Bari, Italy

Consultant, April - June 2018

Biostatistician, August -  December  2017
Department of Basic Medical Sciences, Neuroscience and Sense Organs, University of Bari “Aldo Moro”, Bari, Italy


Italian National Scientific Qualification as Associate Professor (2023)
Ministero dell’Università e della Ricerca, Italy

PhD in Health Data Sciences (2021)
Charité – Universitätsmedizin Berlin, Berlin, Germany

M.Sc. in Biostatistics (2016)
University of Milano-Bicocca, Milan, Italy

B.Sc. in Statistical Sciences (2014)
University of Bari “Aldo Moro”, Bari, Italy


•    Piccininni M, Wechsung M, Van Calster B, Rohmann JL, Konigorski S, van Smeden M. Understanding random resampling techniques for class imbalance correction and their consequences on calibration and discrimination of clinical risk prediction models. J Biomed Inform. 2024 Jun 5:104666. doi.org/10.1016/j.jbi.2024.104666
•    Piccininni M, Stensrud MJ. Using Negative Control Populations to Assess Unmeasured Confounding and Direct Effects. Epidemiology. 2024 May 1;35(3):313-319. doi.org/10.1097/EDE.0000000000001724
•    Schwabauer E, Piccininni M, Freitag E, Ebinger M, Geisler F, Harmel P, Hille A, Lorenz-Meyer I, Rohrpasser-Napierkowski I, Kurth T, Rohmann JL, Endres M, Schlunk F, Weber J, Wendt M, Audebert HJ. Effects of Mobile Stroke Unit dispatch on blood pressure management and outcomes in patients with intracerebral haematoma: Results from the Berlin_Prehospital Or Usual Care Delivery in acute Stroke (B_PROUD) controlled intervention study. Eur Stroke J. 2023 Nov 28:23969873231213156. doi.org/10.1177/23969873231213156
•    Fehr J, Piccininni M, Kurth T, Konigorski S. Assessing the transportability of clinical prediction models for cognitive impairment using causal models. BMC Med Res Methodol. 2023 Aug 19;23(1):187. doi.org/10.1186/s12874-023-02003-6
•    Piccininni M, Kurth T, Audebert HJ, Rohmann JL. The Effect of Mobile Stroke Unit Care on Functional Outcomes: An Application of the Front-door Formula. Epidemiology. 2023 Sep 1;34(5):712-720. doi.org/10.1097/EDE.0000000000001642
•    Piccininni M, Brinks R, Rohmann JL, Kurth T. Estimation of migraine prevalence considering active and inactive states across different age groups. J Headache Pain. 2023 Jul 11;24(1):83. doi.org/10.1186/s10194-023-01624-y
•    Wong A, Kramer SC, Piccininni M, Rohmann JL, Kurth T, Escolano S, Grittner U, de Cellès MD. Using LASSO regression to estimate the population-level impact of pneumococcal conjugate vaccines. Am J Epidemiol. 2023 Mar 17:kwad061. Epub ahead of print. doi.org/10.1093/aje/kwad061
•    Logroscino G, Piccininni M, Graff C, Hardiman O, Ludolph AC, Moreno F, Otto M, Remes AM, Rowe JB, Seelaar H, Solje E, Stefanova E, Traykov L, Jelic V, Rydell MT, Pender N, Anderl-Straub S, Barandiaran M, Gabilondo A, Krüger J, Murley AG, Rittman T, van der Ende EL, van Swieten JC, Hartikainen P, Stojmenović GM, Mehrabian S, Benussi L, Alberici A, Dell'Abate MT, Zecca C, Borroni B, FRONTIERS group. Incidence of Syndromes Associated With Frontotemporal Lobar Degeneration in 9 European Countries. JAMA Neurol. Published online January 30, 2023. doi.org/10.1001/jamaneurol.2022.5128
•    Gonçalves ASO, Rohmann JL, Piccininni M, Kurth T, Ebinger M, Endres M, Freitag E, Harmel P, Lorenz-Meyer I, Rohrpasser-Napierkowski I, Busse R, Audebert HJ. Economic Evaluation of a Mobile Stroke Unit Service in Germany. Ann Neurol. 2023 Jan 13. doi.org/10.1002/ana.26602
•    Rohmann JL, Huerta-Gutierrez R, Audebert HJ, Kurth T, Piccininni M. Adjusted horizontal stacked bar graphs (“Grotta bars”) for consistent presentation of observational stroke study results. European Stroke Journal. 2023;0(0). doi.org/10.1177/23969873221149464
•    Battista P, Piccininni M, Montembeault M, Messina A, Minafra B, Miller BL,  Henry ML, Gorno-Tempini ML, Grasso SM (2022) Access, referral, service provision and management of individuals with primary progressive aphasia: A survey of speech-language therapists in Italy. International Journal of Language & Communication Disorders, 1–15. doi.org/10.1111/1460-6984.12843
•    Rohmann JL, Piccininni M, Ebinger M, Wendt M, Weber JE, Schwabauer E, Geisler F, Freitag E, Harmel P, Lorenz-Meyer I, Rohrpasser-Napierkowski I, Nolte CH, Nabavi DG, Schmehl I, Ekkernkamp A, Endres M, Audebert HJ. Effect of mobile stroke unit dispatch in all patients with acute stroke or TIA. Ann Neurol. 2022 Oct 30. Epub ahead of print. PMID: 36309933. doi.org/10.1002/ana.26541
•    Piccininni M. Counterfactual fairness: The case study of a food delivery platform’s reputational-ranking algorithm. Front. Psychol. 13:1015100 (2022). doi.org/10.3389/fpsyg.2022.1015100
•    Piccininni M, Rohmann JL, Wechsung M, Logroscino G, Kurth T. Should Cognitive Screening Tests Be Corrected for Age and Education? Insights From a Causal Perspective. Am J Epidemiol. 2023 Jan 6;192(1):93-101. doi.org/10.1093/aje/kwac159
•    Siegert K, van Loon W, Gai PP, Rohmann JL, Piccininni M, Näher A-F, Boloor A, Shenoy D, Mahabala C, Kulkarni SS, Kumar A, Wedam J, Gai P, Devi R, Jain A, Kurth T, Mockenhaupt FP. The Effect of Socioeconomic Factors and Indoor Residual Spraying on Malaria in Mangaluru, India: A Case-Control Study. International Journal of Environmental Research and Public Health. 2021; 18(22):11853. doi.org/10.3390/ijerph182211853
•    Raggi A, Monasta L, Beghi E, Caso V, Castelpietra G, Mondello S, Giussani G, Logroscino G, Magnani FG, Piccininni M, Pupillo E, Ricci S, Ronfani L, Santalucia P, Sattin D, Schiavolin S, Toppo C, Traini E, Steinmetz J, Nichols E, Ma R, Vos T, Feigin V, Leonardi M. Incidence, prevalence and disability associated with neurological disorders in Italy between 1990 and 2019: an analysis based on the Global Burden of Disease Study 2019. J Neurol. 2021 Sep 8. Epub ahead of print. doi.org/10.1007/s00415-021-10774-5
•    Zoccolella S, Capozzo R, Quaranta VN, Castellana G, Marra L, Liotino V, Giorgio V, Simone IL, Resta O, Piccininni M, Tortelli R, Logroscino G. Reduction of Sniff Nasal Inspiratory Pressure (SNIP) as an Early Indicator of the Need of Enteral Nutrition in Patients with Amyotrophic Lateral Sclerosis. Brain Sciences. 2021; 11(8):1091. doi.org/10.3390/brainsci11081091
•    Borroni B, Graff C, Hardiman O, Ludolph AC, Moreno F, Otto M, Piccininni M, Remes AM, Rowe JB, Seelaar H, Stefanova E, Traykov L, Logroscino G; FRONTIERS. FRONTotemporal dementia Incidence European Research Study-FRONTIERS: Rationale and design. Alzheimers Dement. 2021 Aug 2. doi.org/10.1002/alz.12414
•    Schulz JB, Berlit P, Diener HC, Gerloff C, Greinacher A, Klein C, Petzold GC, Piccininni M, Poli S, Röhrig R, Steinmetz H, Thiele T, Kurth T; DGN SARS-CoV-2 Vaccination Study Group. COVID-19 vaccine-associated cerebral venous thrombosis in Germany. Ann Neurol. 2021 Oct; 90(4): 627-639. doi.org/10.1002/ana.26172
•    Barulli MR, Piccininni M, Brugnolo A, Musarò C, Di Dio C, Capozzo R, Tortelli R, Lucca U and Logroscino G. The Italian Version of the Test Your Memory (TYM-I): A Tool to Detect Mild Cognitive Impairment in the Clinical Setting. Front. Psychol. 11:614920 (2021). doi.org/10.3389/fpsyg.2020.614920
•    Tortelli R, Zecca C, Piccininni M, Benmahamed S, Dell'Abate MT, Barulli MR, Capozzo R, Battista P, Logroscino G. Plasma Inflammatory Cytokines Are Elevated in ALS. Front. Neurol. 11:552295 (2020). doi.org/10.3389/fneur.2020.552295
•    Al-Hassany L, Haas J, Piccininni M, Kurth T, Maassen Van Den Brink , Rohmann JL. Giving Researchers a Headache – Sex and Gender Differences in Migraine. Front. Neurol. 11:549038 (2020). doi.org/10.3389/fneur.2020.549038
•    Meier K, Glatz T, Guijt MC, Piccininni M, van der Meulen M, Atmar K, Jolink AC, Kurth T, Rohmann JL, Zamanipoor Najafabadi AH, COVID-19 Survey Study group (2020). Public perspectives on protective measures during the COVID-19 pandemic in the Netherlands, Germany and Italy: A survey study. PLoS ONE 15(8): e0236917. doi.org/10.1371/journal.pone.0236917
•    Piccininni M, Konigorski S, Rohmann JL, Kurth T. Directed acyclic graphs and causal thinking in clinical risk prediction modeling. BMC Med Res Methodol 20, 179 (2020). doi.org/10.1186/s12874-020-01058-z
•    Piccininni M, Rohmann JL, Logroscino G, Kurth T. Blockchain-Based Innovations for Population-Based Registries for Rare Neurodegenerative Diseases . Frontiers in Blockchain . 2020 May 19; 3:20 doi.org/10.3389/fbloc.2020.00020    
•    Piccininni M, Rohmann JL, Foresti L, Lurani C, Kurth T. Use of all cause mortality to quantify the consequences of covid-19 in Nembro, Lombardy: descriptive study. BMJ 2020; 369 :m1835. doi.org/10.1136/bmj.m1835
•    Piccininni M, Rohmann JL, Huscher D, Mielke N, Ebert N, Logroscino G, Schäffner E, Kurth T. Performance of risk prediction scores for cardiovascular mortality in older persons: External validation of the SCORE OP and appraisal. PLoS One. 2020 Apr 9;15(4):e0231097. doi.org/10.1371/journal.pone.0231097
•    Logroscino G, Kurth T, Piccininni M. The Reconstructed Cohort Design: A Method to Study Rare Neurodegenerative Diseases in Population-Based Settings. Neuroepidemiology. 2020 Jan 7:1-9. doi.org/10.1159/000502863
•    GBD 2017 Italy Collaborators. Italy's health performance, 1990-2017: findings
from the Global Burden of Disease Study 2017. Lancet Public Health. 2019
Dec;4(12):e645-e657. doi.org/10.1016/S2468-2667(19)30189-6
•    Zecca C, Brescia V, Piccininni M, Capozzo R, Barone R, Barulli MR, Logroscino G. Comparative evaluation of two immunoassays for cerebrospinal fluid
β-Amyloid(1-42) measurement. Clin Chim Acta. 2019 Jun;493:107-111. doi.org/10.1016/j.cca.2019.02.033
•    Logroscino G, Piccininni M, Binetti G, Zecca C, Turrone R, Capozzo R, Tortelli R, Battista P, Bagoj E, Barone R, Fostinelli S, Benussi L, Ghidoni R, Padovani A, Cappa SF, Alberici A, Borroni B. Incidence of frontotemporal lobar degeneration in Italy: The Salento-Brescia Registry study. Neurology. 2019 May 14;92(20):e2355-e2363. doi.org/10.1212/WNL.0000000000007498
•    Depenni R, Cossu Rocca M, Ferrari D, Azzarello G, Baldessari C, Alù M, Nolé F, Codecà C, Boscolo G, Piccininni M, Cavalieri S, Bossi P. Clinical outcomes and prognostic factors in recurrent and/or metastatic head and neck cancer patients treated with chemotherapy plus cetuximab as first-line therapy in a real-world setting. Eur J Cancer. 2019 May 10;115:4-12. doi.org/10.1016/j.ejca.2019.03.022
•    Barulli MR, Piccininni M, Di Dio C, Musarò C, Grasso A, Tursi M, Iurillo A, Lozupone M, Capozzo R, Tortelli R, Simone IL, Panza F, Logroscino G. Episodic memory and learning rates in amyotrophic lateral sclerosis without dementia. Cortex. 2019 Mar 19;117:257-265. doi.org/10.1016/j.cortex.2019.03.003
•    GBD 2016 Neurology Collaborators. Global, regional, and national burden of neurological disorders, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2019 May;18(5):459-480.  doi.org/10.1016/S1474-4422(18)30499-X
•    Logroscino G, Piccininni M. Amyotrophic Lateral Sclerosis Descriptive Epidemiology: The Origin of Geographic Difference. Neuroepidemiology 2019;52:93-103. doi.org/10.1159/000493386
•    Panza F, Lozupone M, Sardone R, Battista P, Piccininni M, Dibello V, La Montagna M, Stallone R, Venezia P, Liguori A, Giannelli G, Bellomo A, Greco A, Daniele A, Seripa D, Quaranta N, Logroscino G. (2018). Sensorial frailty: age-related hearing loss and the risk of cognitive impairment and dementia in later life. Therapeutic Advances in Chronic Disease. doi.org/10.1177/2040622318811000
•    GBD 2016 Motor Neuron Disease Collaborators. Global, regional, and national burden of motor neuron diseases 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol. 2018 Nov 2. pii: S1474-4422(18)30404-6.
•    Battista P, Catricalà E, Piccininni M, Copetti M, Esposito V, Polito C, Miozzo A, Gobbi E, Cuoco S, Boschi V, Picillo M, Sorbi S, Barone P, Iannaccone S, Garrard P, Logroscino G, Cappa SF. Screening for Aphasia in NeuroDegeneration for the Diagnosis of Patients with Primary Progressive Aphasia: Clinical Validity and Psychometric Properties. Dement Geriatr Cogn Disord. 2018;46(3-4):243-252. doi.org/10.1159/000492632
•    Lozupone M, Panza F, Piccininni M, Copetti M, Sardone R, Imbimbo BP, Stella E, D'Urso F, Rosaria Barulli M, Battista P, Grasso A, Tortelli R, Capozzo R, Coppola F, Isabel Abbrescia D, Bellomo A, Giannelli G, Quaranta N, Seripa D, Logroscino G. Social Dysfunction in Older Age and Relationships with Cognition, Depression, and Apathy: The GreatAGE Study. J Alzheimers Dis. 2018;65(3):989-1000. doi.org/10.3233/JAD-180466
•    Zecca C, Tortelli R, Panza F, Arcuti S, Piccininni M, Capozzo R, Barulli MR, Barone R, Cardinali R, Abbrescia D, Seripa D, Brescia V, Logroscino G.  Plasma β-amyloid1–42 reference values in cognitively normal subjects. Journal of the Neurological Sciences. 2018; 391 (2018): 120-126.
•    Logroscino G, Marin B, Piccininni M, Arcuti S, Chiò A, Hardiman O, Rooney J, Zoccolella S, Couratier P, Preux PM, Beghi E; for EURALS. Referral bias in ALS epidemiological studies. PLoS One. 2018 Apr 16;13(4):e0195821.
•    Battista P, Miozzo A, Piccininni M, Catricalà E, Capozzo R, Tortelli R, Padovani A, Cappa S, Logroscino G. Primary Progressive Aphasia: a review of Neuropsychological tests for the assessment of speech and language disorders. Aphasiology. 2017; 31 (12): 1359-1378. doi.org/10.1080/02687038.2017.1378799