Database architectures are fundamentally changing due to new technologies and new requirements. Oracle Autonomous Database (ADB) is the premier cloud database that combines decades of database automation techniques and database infrastructure development, with the power of machine learning to deliver a fully autonomous database that revolutionizes data management. This talk provides a brief overview of ADB, dives deeper into innovative use of modern hardware technologies including PMEM and RoCE to deliver high-throughput data access and low latency data modification performance, and discusses deployment flexibility enabled by the Oracle Cloud Infrastructure gen-2 network design.